Looked at
Jersey Street numbers 72, 84, 131 on
1891 census - not much help
No 72 Elizabeth CAIN, wid children
JAMES, Catherine & Joseph (same address 1899 marriage cert.) same address in 1881
James Born 26 Oct 1867 Bpt. 3 Nov 1867 St. Patrick's Father Mattheu Mother Elizabeth McGuire
No 84 William DUCIE & his sister Margaret
No 131 Richard WHITE & his family (he's at that address in 1881)
This is the only SMITH family I can see living in Jersey Street in 1891

No 66 William Mars Head son in law James SMITH 37 wife Hannah (nee Mars) 37, dau Ellen 8 (mmn MARS), nephew William Smith 21
Are these all the children of James & Mary Jane?Maria Elizabetha Cain 24 Jul 1896 Baptism 2 Aug 1896 Manchester
Jacobi, Maria Joannae
Joseph Cain 30 Dec 1897 Baptism 9 Jan 1898 Manchester
Jacobi, Mariae Johannae
Margarita Cain 13 Jul 1899 Baptism 23 Jul 1899 Manchester
Jacobi, Mariae
Josephina Cain 13 Jul 1899 Baptism 23 Jul 1899 Manchester
Jacobi, Mariae
Catherina Cain 29 Oct 1900 Baptism 10 Nov 1900 Manchester
Jacobi, Mariae Jane
Jacobus Cain 18 Nov 1903 Baptism 6 Dec 1903 Manchester
Jacobi, Mariae Jeannae
Gertruda Cain 30 Jun 1906 Baptism 10 Jul 1906 Manchester
Jacobi, Mariae Joannae
Could naming patterns of James & Mary's children help narrow the search

We know James' parents Matthew, Elizabeth and siblings Catherine & Joseph (from census)
and from their m/c
father's Matthew Cain & John Smith
witnesses were Margaret Smith & Joseph Cain