I believe they went to the US (Philadelphia) shortly after their marriage. They had many children after arriving in the US.
I'm not 100% sure they are related to me, and the existing research I found isn't the most reliable.
I have relatives Catherine O'Hara born 1847 in the Ballina area and James O'Hara born 18 Nov 1852 in Bunree to parents James O'Hara and Kitty/Catherine Melvin. Catherine had several children in Bunree.
However, the civil marriage record for Mary lists her father as Michael O'Hara.
Mary's Philadelphia death certificate lists her mother's maiden name as Melvin, which would very likely make her related to me, but haven't found any other collaborating evidence. Which is why I was hoping the church marriage record would shed some light there.