I've got a chance to look at a concrete example which might effect DNA cm amounts 
DNA results just in but I think I can see high DNA matches to some descendants of 
Thomas B.+ Eliza H
Caroline Ann  C... (nee B.)’s father 
Thomas John B was a brother of Eliza Caroline B, wife of Alfred C
. Eliza Caroline was born in Kensington in 1866 and Thomas John was born in Chelsea in 1871. 
Both were children of Thomas B. Cab Driver and Eliza Nee H
This means that Caroline + Alfred C.... s son  Eric Alfred C..’s paternal grandmother and maternal grandfather were brother and sister.
I'm looking at DNA matches for their child 
Ive used initials for  surnames for privacy reasons 
But will be able to compare results with anyone who has a similar scenario.
Ps the 2 great grandparents in this case are both from paternal side