I agree that Wain is a mistranscription, though the original isn't all that clear and I can see how a transcriber might have read it as Wain
There's a 14-year-old John in the family, and there is a birth of John Winn, mother's maiden surname MacInally, in Newcastle in 1846. In 1851 there's a family consisting of Francis, 28; wife Margaret, 25, son Francis, 8, son John, 5, and daughter Margaret, 2. Margaret Winn, 25, died in Newcastle in 1851 aged 25 and another Margaret Winn, aged 3, died later the same year. So it does look as if Francis as married before.
As CaroleW says, you need to get a copy of the marriage certificate. Ann's birth certificate might also be of interest.