this book might help, if any of them were in New England early. It is at archive.org. there are 3 or 4 volumes, find the one for "P" and look through it.
A Genealogical Dictionary of the First Settlers of New England, Showing Three Generations of Those Who Came Before May, 1692, on the Basis of Farmer's Register. Author: Savage, James, 1784-1873
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Googling: "Penrose Great Migration 1620s" might help also, or change the date, or replace "Great Migration" with "Virginia" "Massachusetts" "Pennsylvania" "Maryland" or the state/locality of your choice.
I found a Penrose referred to here
https://www.wikitree.com/wiki/Nicholson-89He was in the late 1600s in "Salem" somewhere. I didn't look closely enough to see which Salem--Mass., New Jersey or who knows where else. There could be a Salem in every state in the union, for all I know.