Good afternoon,
Macclesfield to Spitalfields is 163 miles, 2 days 6 hrs to walk it according to g maps. Given they wouldn't walk 24hrs a day and probably pulling a cart with goods on then I would say 5 days each way. Of course, the rds wouldn't have been so good then.
When Thomas Smith exhibited his Sussex trugs at the great exhibition in London. Queen Victoria was very taken with them so ordered some for herself and many family members. Thomas made the order then walked from Herstmonceux, Sussex to Buckingham Palace with a "wheel" of trugs. He delivered them personally and became the only trug maker with a royal warrant. Then walked home again, about 2 days each way.
Every year farmers and stockmen would walk herds of cattle, flocks of sheep and geese etc to Spitalfields market for sale. Some from places quite a distance from London.
John915