Many thanks for the replies. Andrew settled in the tiny village of Richmond near Chicago. He married Katherine Welch at the nearest Catholic parish which was in McHenry, Illinois (a fair distance away from Richmond considering the transportation of the time) in 1860. They lived in Richmond til death in 1901. All records merely list him as from "Ireland".
I did find a brother Frank who settled in Cincinnati, Ohio but have found even less information about him.
Griffith's Valuation lists four Andrews in County Cavan, Parish of Kinawley. The Ulster Historical Foundation found that the name was rare but found in Counties Cavan and Fermanagh in the 1800's.
Really appreciate the efforts to help in my years long search,
Mike