The only possible connection I can see, which isn't too helpful is that there is a William Locker b 1842, Buxton.
1861 2941/6/5 he is a visitor, unmarried in Manchester
1871 3983/87/15 He is married, with two brothers (I assume) and living in Openshaw - close to Gorton
1881 4019/50/34 he is a widow living with his brother in Beswick, Manchester - close to Openshaw.
There is no sign of William Isaac. I haven't yet found a marriage for William. He is not the one in some indexes marrying Harriet Ann Moss in 1869- he is Cocker.