It generally is sad finds in family research.
The most tragic side of my family is my Gloucestershire gt gt gt grandfather John Mealing. His son William killed his fiancee in a fit of insanity and spent the rest of his life in Broadmoor Criminal Lunatic Asylum. John's daughter (my gt gt grandmother) Ann had twins that died and she herself died at the age of 38 after childbirth. John's other children left the village and several went to Glamorganshire - one travelled as far as the United States. When widowed, John tried to commit suicide by cutting his throat - but he failed. He was nursed at home by his daughter but against his and her will he was taken to the Workhouse in Cirencester, where he died 20 days after his attempt to kill himself. That's always struck me as desperately sad.