How sad. It sounds as though there might have been some genetic problem with that family.
When I did some transcribing for Freecen, there was an entry that brought a tear to my eye for different reasons. It was for Margaret Pinkney, a 60 year old schoolmistress in the village of Barton, North Riding of Yorkshire, but enumerated in the district of Darlington, County Durham. I really hope that her husband James age 77 wasn't part of the school staff

RG9/3682/67/4 (I hope I've got that right!