In the 1861 census it is hard to read but head of household at 20 George Street looks like Herman G***ner, wife Annie, a boarder Charles B? Fontana, commercial clerk. I think the couple are Herman Gwinner and Annie Cohan who married in Liverpool in 1857. In 1871 I think they may be in Brighton on the Kings Road (on holiday, looks like - RG10/1085 folio 48 page 42) so they may be still at the 20 George Street address.
Another possiblity is the doctor John B. Potter who was living at that address by 1873 as shown in this letter he wrote:
http://www.bmj.com/cgi/reprint/2/678/770.pdf(probably John Baptiste Potter)
In 1871 he's in the area lodging at 56 Conduit Street with another medical family.
And then books.google.com suggests (from the Journal of the Society of Arts, Volume 13) that in 1865 Albert Westhead and Edwd S Westhead were living there. Now he is interesting because I think this is a Manchester link - in the 1871 census there's Albert Westhead, 28, an undergraduate at Cambridge living with his parents Edward and Harriet R and married sister Catherine Hare(?), all of them born Manchester but at that time living in Surrey.
The parents of Albert appear to have been Edward Westhead and Harriet Royle Chappell, in case those names ring any bells.