Hi LC,
Here are Charles, Caroline and their daughters in the 1861 census living at 10 William Street, St Alkmund:
Charles Topham, Head, Married, 30, Millwright, Derby Derbyshire
Caroline Topham, Wife, Married, 27, Dressmaker, Stapleford Nottinghamshire
Eliza Topham, Daughter, Unmarried, 4, [no occupation], Derby Derbyshire
Mary Elizabeth Topham, Daughter, Unmarried, 2, [no occupation], Derby Derbyshire
In 1851 Jeremiah Topham and his family were living at 88 Bridge Street, St Alkmund and by 1861 had moved to 12 Garden Street, St Alkmund.
Caroline's parents were Edward Brown and Elizabeth Catley. They married on 13 November 1826 in Newark-on-Trent, Nottinghamshire. They had 5 children: Thomas, Charles, William, Caroline and Eliza.
I hope this helps! If I can help with anything else just let me know.
All the best,
Ashlee