1841 census has the following:
28, Coleshill Street, St. George, Hanover Square
Louisa Currie, 39, Housekeeper, not born in county
Robt, 20, Clerk - b.i.c.
Ann, 20, b.i.c
Louisa, 5 "
So it looks as if Charles has died, leaving Louisa with three offspring at home.
I'll see if I can find his death registration.
Jen