Just an update to my original post with information I found last night (and am still following up these leads):
James Driscoll (c1825 Ireland-?) m.(1867 Cardiff, Wales) Mary Keefe (c1829 Ireland-?). Known children:
1. Johanna/Anne O'Driscoll (1851 Cardiff-1933 N.Y.) m. Michael McCoy.
2. Timothy (c1854 Cardiff) m. Hester Brown (she went to U.S.1912 with son Daniel but husband Timothy was still alive. Hester was still there in 1920). Daughters Agnes, Annie and Lizzie also went to U.S.- Connecticut. 1910 Lizzie living with sister Agnes and family. When Lizzie arrived in U.S. in 1905 she was going to her aunt Mrs. Jones. Mrs. Jones was Mary E. Jones who is possibly the Mary Driscoll (born c1861) below. 3. Ellen/Nellie Driscoll (1859 Cardiff-1914 Connecticut) m. George Clifford.
4. Mary Driscoll (c1861 Cardiff).
5. Daniel J. Driscoll (1865 Cardiff-1945 Connecticut) m. Esther Martell.