This could well be Elizabeth S Nicholas on the 1851...
147 High Street, Portsmouth
John Nicholas, head, M, 47, Tailor employing 1 man, born Portsmouth
Elizabeth S Nicholas, wife, M, 48, born Portsmouth
Clara Nicholas, daughter, U, 22, at home, born Portsmouth
John J Nicholas, son, U, 19, Tailor, born Portsmouth
Elizabeth S Nicholas, daughter, U, 16, at home, born Portsmouth
Edwin A Nicholas, son, U, 14, at home, born Portsmouth
Emma L Nicholas, daughter, U, 12, Scholar, born Portsmouth
Charles O Nicholas, son, U, 6, Scholar, born Portsmouth
George A Nicholas, son, U, 4, Scholar, born Portsmouth
HO107/1658/600/7