What an interesting thread this is!
My four are:
Eliza Tait Wilson (1856-1927), born in Edinburgh, apparently had some sort of medical training very early on - married a presbyterian minister, they later emigrated to Alberta, Canada and he left her in charge of the ranch while he and two sons returned to fight in WW1
Clara Jane Tancock (1861-1942), born in Devon but married an itinerant preacher and travelled to Australia with him on a missionary journey - when they returned she worked in the family draper's business to support his ministry and also managed to raise five children
Louisa Clements (1866-1931), only daughter of a teenage runaway marriage, orphaned at 2 when her dad died of smallpox

mum then remarried and Louisa was brought up by grandparents, working in the family laundry from the age of 12. She went on to have at least 8 children
Eveline Esther Carpenter (1871-1955), second of nine children, went into service at the age of 12. She had two children, one baby very premature whose life she saved by wrapping him in cotton wool and feeding him drops of milk with a fountain pen filler - only to see him killed in action in WW1

She survived both of them and is the only one I remember, though I have photos of all of them.
As someone else has said earlier on this thread - I do think of them when my own life seems hard - they had to cope with so much!
Veron