Jack,
Don't know about your 9aging) specific query but in the mid 1800s there was a number of Kirkpatrick brothers on the IOW and a couple of unmarried sisters lived together in the Henley on Thames or Reading area. LDS records may shed some light on them.
One (a James) went bankrupt - a (free) search for Kirkpatrick on Google will throw up some those details - I saw a reference earlier today to Newport, Carisbrooke etc.
Another was a George. I think there may have been a William and a knighthood somewhere there. I think they were lawyers.
My own notes show that on 20.08.1858 a James Kirkpatrick died at Newport IOW He was brother of a Samuel who was a grocer of 91 Queen St, Cheapside London. I don't know of a link to the Berkshire / Aston Tirrold & Uffington line but there may be one- certainly descendants of that family migrated to Caversham, Henley and London areas.