Hi Patricia!
The "oldest" Twilley I have is John, born ca. 1802. Looks as though his father was a John, too.
John's son Frederick was born in 1837 in Strand/London and was a Jewel Case Maker. He had many children, born in Marylebone and Strand, e.g. Frederick (1859) also Jewel Case Maker, Alfred (1861), Rosetta (1864).
1859 Fred also had lots of kiddies, incl. a Frederick born 1880 in St. Pancras.
Looks as though most of the family stayed in the Pancras area.
Don't know if this helps...

Thanks,
Karen