Hi Valerie,
It's all frustrating because all I know is that
1. Denis O'Brien was born in Bandon in 1846.
2. His brother Cornelius was born within five years of 1846. That's all I know about the O'Brien family in Ireland, so unfortunately do not recognize any of your names.
3. They emigrated to Conshohocken, Pennsylvania, US, around 1868. There may have been other O'Briens in Conshohocken that preceded them, but I do not know who they were.
4. Hourihanes and my O'Briens are either related or were derived from each other, or both. This may have happened 200-300 years ago.
Have you uploaded your DNA to any site? I am on FTDNA, Geni, MyHeritage, gedmatch genesis, and Ancestry. I am distantly related to Hourihanes on FTDNA and Ancestry, at least. If you do use of of those sites, upload your DNA to gedmatch genesis, if you haven't done so, and I can probably find you if there is a relationship.
You do not have to be male for most of those sites. For example, FTDNA has a Family Finder for everyone. yDNA is for males, but mtDNA looks at female lines, although mutations are less frequent there.
Great talking with you.
Jack