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DIRECTORY OF IRISH BORN PEOPLE LIVING IN MANCHESTER IN 1861

1) Sarah Kelly mother & widow age 60 born County down
22 Back Irwell street, Deansgate.

2) Sarah Kelly Mother-in-law widow age 60
9 Lower Ormod Street, Chorlton on Medlock.

3) Sarah Kelly sister  unmarried age 28
16 German street, Ancoats.

That's interesting, I didn't know that!
I have a photo which has Angel St on the back.  I recognised Angel St when it was  just mentioned on here and tried to remember where I saw it.  I've just looked at the photos my famly sent me and one has "Rose and kate at The Angel House, Manchester " on the back of it.  The photo was taken in approx 1933 and is of William's daughter / niece Rose and Florence's daughter Kathleen so I wonder if they had family living there still, from William's side.
Suddenly a photo has made your search results likely!

Angel street was part of Angel meadows area and was one of the very poorest parts of Manchester with a big Irish community as did Ancoats.
You can check some of the records on line for around these areas.
I spotted two baptiums with close to your Florence & Rose Ann Smith on there.

http://www.mlfhs.org.uk/data/catholic_search.php

Also st. Chad's church is a two min walk from Angel street.

http://www.genuki.org.uk/big/eng/LAN/Cheetham/StChad.shtml

You can read a little about the area on these links

http://www.lhi.org.uk/docs/St_Michaels_flags.pdf

http://www.mangeogsoc.org.uk/egm/3_2.pdf

As for other family members I don't know again. I heard he was estranged from his family.

BucksExile

If he was born in Salford, then could this be the family 1901?
14 Broster street Salford
Thomas Butterworth 39 Iron foundry worker born Salford
Mary A Butterworth 32  born Manchester
Frances Butterworth 6 born Salford
Louisa Butterworth 5 born Salford
James Butterworth 3 born Manchester
John Butterworth 2 Months born Salford

RG13; Piece: 3730; Folio: 48; Page: 15.

Hi, it might be worth you either emailing or phoning Salford local history library and asking if they would be so kind to look for any obituary in there local papers?

    local.history[at]salford.gov.uk   replace [at]  with @ in the email address.
    Tel: 0161 778 0814
    http://www.salford.gov.uk/lhlibrary.htm

Explain where you live and a trip there is not an option, they are very good.
You could also ask for the same from this rootschat who is making a trip to Manchester soon i think?

http://www.rootschat.com/forum/index.php/topic,537284.0.html

Good luck